Approximate computing design exploration through data lifetime metrics

When designing an approximate computing system, the selection of the resources to modify is key. It is important that the error introduced in the system remains reasonable, but the size of the design exploration space can make this extremely difficult. In this paper, we propose to exploit a new metric for this selection: data lifetime. The concept comes from the field of reliability, where it can guide selective hardening: the more often a resource handles "live" data, the more critical it be-comes, the more important it will be to protect it. In this paper, we propose to use this same metric in a new way: identify the less critical resources as approximation targets in order to minimize the impact on the global system behavior and there-fore decrease the impact of approximation while increasing gains on other criteria

Suppression of ablation in femtosecond double pulse experiments

We report the physical reasons of a curious decrease in the crater depth observed for long delays in experiments with femtosecond double pulses. Detailed hydrodynamic modeling demonstrates that the ablation mechanism is dumped when the delay between the pulses exceeds the electron-ion relaxation time. In this case, the interaction of the second laser pulse with the expanding target material leads to the formation of the second shock wave suppressing the rarefaction wave created by the first pulse. The evidence of this effect follows from the pressure and density profiles obtained at different delays after the first laser pulse.Comment: Submitted to one of the APS Journal

Wave-Based Analysis of Large Nonlinear Photovoltaic Arrays

In this paper, a novel analysis method based on wave digital (WD) principles is presented. The method is employed for modeling and efficiently simulating large photovoltaic (PV) arrays under partial shading conditions. The WD method allows rapid exploration of the current-voltage curve at the load of the PV array, given: the irradiation pattern, the nonlinear PV unit model (e.g., exponential junction model with bypass diode) and the corresponding parameters. The maximum power point can therefore easily be deduced. The main features of the proposed method are the use of a scattering matrix that is able to incorporate any PV array topology and the adoption of independent 1-D nonlinear solvers to handle the constitutive equations of PV units. It is shown that the WD method can be considered as an iterative relaxation method that always converges to the PV array solution. Rigorous proof of convergence and results about the speed of convergence are provided. Compared with standard spice-like simulators, the WD method results to be 35 times faster for PV arrays made of some thousands elements. This paves the way to possible implementations of the method in specialized hardware/software for the real time control and optimization of complex PV plants

Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection.

A majority of individuals infected with human immunodeficiency virus (HIV) have inadequate access to antiretroviral therapy and ultimately develop debilitating oral infections that often correlate with disease progression. Due to the impracticalities of conducting host-microbe systems-based studies in HIV infected patients, we have evaluated the potential of simian immunodeficiency virus (SIV) infected rhesus macaques to serve as a non-human primate model for oral manifestations of HIV disease. We present the first description of the rhesus macaque oral microbiota and show that a mixture of human commensal bacteria and "macaque versions" of human commensals colonize the tongue dorsum and dental plaque. Our findings indicate that SIV infection results in chronic activation of antiviral and inflammatory responses in the tongue mucosa that may collectively lead to repression of epithelial development and impact the microbiome. In addition, we show that dysbiosis of the lingual microbiome in SIV infection is characterized by outgrowth of Gemella morbillorum that may result from impaired macrophage function. Finally, we provide evidence that the increased capacity of opportunistic pathogens (e.g. E. coli) to colonize the microbiome is associated with reduced production of antimicrobial peptides

Effects of Heparin and Enoxaparin on APP Processing and Aβ Production in Primary Cortical Neurons from Tg2576 Mice

Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan (GAG) heparin, has been reported to lower Aβ plaque deposition and improve cognitive function in AD transgenic mice

Toxic epidermal necrolysis and Stevens-Johnson syndrome

Toxic epidermal necrolysis (TEN) and Stevens Johnson Syndrome (SJS) are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. Both are rare, with TEN and SJS affecting approximately 1or 2/1,000,000 annually, and are considered medical emergencies as they are potentially fatal. They are characterized by mucocutaneous tenderness and typically hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Currently, TEN and SJS are considered to be two ends of a spectrum of severe epidermolytic adverse cutaneous drug reactions, differing only by their extent of skin detachment. Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infections are well documented causes alongside rare cases in which the aetiology remains unknown. Several drugs are at "high" risk of inducing TEN/SJS including: Allopurinol, Trimethoprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones, carbamazepine, phenytoin, phenobarbital and NSAID's of the oxicam-type. Genetic susceptibility to SJS and TEN is likely as exemplified by the strong association observed in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and SJS induced by carbamazepine. Diagnosis relies mainly on clinical signs together with the histological analysis of a skin biopsy showing typical full-thickness epidermal necrolysis due to extensive keratinocyte apoptosis. Differential diagnosis includes linear IgA dermatosis and paraneoplastic pemphigus, pemphigus vulgaris and bullous pemphigoid, acute generalized exanthematous pustulosis (AGEP), disseminated fixed bullous drug eruption and staphyloccocal scalded skin syndrome (SSSS). Due to the high risk of mortality, management of patients with SJS/TEN requires rapid diagnosis, evaluation of the prognosis using SCORTEN, identification and interruption of the culprit drug, specialized supportive care ideally in an intensive care unit, and consideration of immunomodulating agents such as high-dose intravenous immunoglobulin therapy. SJS and TEN are severe and life-threatening. The average reported mortality rate of SJS is 1-5%, and of TEN is 25-35%; it can be even higher in elderly patients and those with a large surface area of epidermal detachment. More than 50% of patients surviving TEN suffer from long-term sequelae of the disease

A new approach for early dependability evaluation based on formal property checking and controlled mutations

ISBN: 0769524060The interest for early analyses of the functional impact of faults in a circuit is growing, due to the increasing probability of transient faults. However, experiments are often very long, especially when spatial and temporal multiplicity has to be taken into account in the fault model. Formal property checking is an appealing approach to perform comprehensive functional validations but is intended to validate properties only in nominal operation, not after a fault has occurred. This paper proposes a new approach combining formal property checking and the generation of specific circuit mutants to achieve efficient early identification of unacceptable effects of multiple faults

Towards modeling for dependability of complex integrated circuits

International audienc

Integrated systems security: hardware-based threats and solutions

International audienc

Introduction to the special session on secure implementations

ISBN: 0769524060This paper briefly introduces online testing and its evolution towards very sub micron technologies. How secure circuit designers and online testing experts collaboration can help detect online the occurrence of natural faults that may be used as a basis to counter fault-based attacks taking into account the particular needs of secure application